abstract：:With the aim to investigate the mechanism of Cu(I) transport by Wilson ATPase (ATP7B), we have studied the interaction of the peptides 2K10p (CH(3)CO-Lys-Gly-Met-Thr-Cys-Ala-Ser-Cys-Val-His-Asn-Lys-CONH(2)), and 2K8p (CH(3)CO-Lys-Leu-Cys-Ile-Ala-Cys-Pro-Cys-Ser-Lys-CONH(2)), part of the sixth metal binding domain (WD6...

journal_title：Journal of inorganic biochemistry

authors： Myari A,Hadjiliadis N,Fatemi N,Sarkar B

更新日期：2004-09-01 00:00:00

abstract：:The single crystals of coordinated complexes of neutral erythritol (C4H10O4) with zinc nitrate and europium nitrate were synthesized and studied using FT-IR and single crystal X-ray diffraction analysis. In the structure of Zn(NO3)2.C4H10O4, ZnEN (E denotes erythritol, N represents nitrate), Zn2+ is coordinated to fou...

journal_title：Journal of inorganic biochemistry

authors： Yang L,Su Y,Xu Y,Zhang S,Wu J,Zhao K

更新日期：2004-08-01 00:00:00

abstract：:Ferredoxin:NADP(+) oxidoreductase (FNR) was treated with cadmium and after that its diaphorase reaction in the presence of dibromothymoquinone (DBMIB) or ferricyanide (FeCy, K(3)Fe(CN)(6)) was examined. CdSO(4) (5 mM) caused 50% inhibition after half hour incubation. At least two components were distinguishable in the...

journal_title：Journal of inorganic biochemistry

authors： Grzyb J,Waloszek A,Latowski D,Wieckowski S

更新日期：2004-08-01 00:00:00

abstract：:Lactoferrin (Lf) is a mammalian iron binding protein present in external secretions and in polymorphonuclear leukocytes. Its role in host defense mechanisms related to the non-immune defense system has been definitively established. Lf has two identical iron-binding sites, far from each other (44.3 A) and magnetically...

journal_title：Journal of inorganic biochemistry

authors： Fasano M,Fanali G,Polticelli F,Ascenzi P,Antonini G

更新日期：2004-08-01 00:00:00

abstract：:The single mitochondrial type I [2Fe-2S] ferredoxin of the fission yeast Schizosaccharomyces pombe is produced as the carboxy terminal part of the electron-transfer-protein 1 (etp1) and cleaved off during mitochondrial import [Biochemistry 41 (2002) 2311-2321]. The UV/Vis (UV-visible) spectrum of the purified recombin...

journal_title：Journal of inorganic biochemistry

authors： Schiffler B,Bureik M,Reinle W,Müller EC,Hannemann F,Bernhardt R

更新日期：2004-07-01 00:00:00

abstract：:The interactions of proteins with reactive oxygen species (ROS) may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages, and oxidation of the protein backbone resulting in protein fragmentation. In an attempt to elucidate the products of the metal-catalyzed ...

journal_title：Journal of inorganic biochemistry

authors： Kowalik-Jankowska T,Ruta M,Wiśniewska K,Łankiewicz L,Dyba M

更新日期：2004-06-01 00:00:00

abstract：:A new Ru(II) complex, [Ru(bpy)(2)(dhipH3)](ClO4)(2) (in which bpy=2,2'-bipyridine, dhipH(3)=3,4-dihydroxy-imidado[4,5-f][1,10]-phenanthroline), was synthesized and characterized, and the pH effect on the emission spectra of the complex was studied. The interaction of the complex with calf thymus DNA was investigated b...

journal_title：Journal of inorganic biochemistry

authors： Bai GY,Wang KZ,Duan ZM,Gao LH

更新日期：2004-06-01 00:00:00

abstract：:Metal-containing granules were isolated from specimens of the barnacle Tetraclita squamosa collected from a metal contaminated site in Hong Kong. The chemical composition, crystallographic and morphological properties of the deposits were analysed by X-ray powder diffraction, electron microscopy, energy dispersive ana...

journal_title：Journal of inorganic biochemistry

authors： Masala O,O'Brien P,Rainbow PS

更新日期：2004-06-01 00:00:00

abstract：:Reactivity of the dicopper(I) and dicopper(II) complexes supported by novel polyamine ligands L1 (1,11-bis(6-methylpyridin-2-yl)-2,6,10-triaza-2,6,10-tribenzylundecane) and L2 (5-benzyl-1,9-bis(6-methylpyridin-2-yl)-2,8-bis(6-methylpyridin-2-ylmethyl)-2,5,8-triazanonane) towards O(2) and H(2)O(2), respectively, has be...

journal_title：Journal of inorganic biochemistry

authors： Teramae S,Osako T,Nagatomo S,Kitagawa T,Fukuzumi S,Itoh S

更新日期：2004-05-01 00:00:00

abstract：:Recent studies of the reaction mechanism of the molybdenum-containing enzyme xanthine oxidase are presented. The pH-dependence of both the steady-state and rapid reaction kinetics of the enzyme exhibits is bell-shaped, with pK(a)s for the acid and alkaline limbs of 6.6 and 7.4, respectively. These are assigned to ioni...

journal_title：Journal of inorganic biochemistry

authors： Choi EY,Stockert AL,Leimkühler S,Hille R

更新日期：2004-05-01 00:00:00

abstract：:Novel bismuth(III) complexes 1-4 with the tridentate thiosemicarbazone ligand of 2N1S donor atoms [Hmtsc (L1); 2-acetylpyridine (4N-morpholyl thiosemicarbazone)], the pentadentate double-armed thiosemicarbazone ligand of 3N2S donor atoms [H2dmtsc (L3); 2,6-diacetylpyridine bis(4N-morpholyl thiosemicarbazone)] and the ...

journal_title：Journal of inorganic biochemistry

authors： Nomiya K,Sekino K,Ishikawa M,Honda A,Yokoyama M,Chikaraishi Kasuga N,Yokoyama H,Nakano S,Onodera K

更新日期：2004-04-01 00:00:00

abstract：:In order to investigate the low-dose long-term Cr(VI) action on antioxidant enzymes in cultured mammalian cells we estimated the activity of glutathione dependent antioxidant enzymes, catalase and superoxide dismutase (SOD) under various chromium concentrations in human epithelial-like L-41 cells. The long-term action...

journal_title：Journal of inorganic biochemistry

authors： Asatiani N,Sapojnikova N,Abuladze M,Kartvelishvili T,Kulikova N,Kiziria E,Namchevadze E,Holman HY

更新日期：2004-03-01 00:00:00

abstract：:A series of new iron(III) and copper(II) complexes of bovine serum transferrin (BTf), with carbonate and/or oxalate as the synergistic anion, are presented. The complexes [Fe(2)(CO(3))(2)BTf], [Fe(2)(C(2)O(4))(2)BTf], [Cu(2)(CO(3))(2)BTf] and [Cu(C(2)O(4))BTf] were prepared by standard titrimetric techniques. The oxal...

journal_title：Journal of inorganic biochemistry

authors： Shongwe MS,Smith R,Marques HM,van Wyk JA

更新日期：2004-02-01 00:00:00

abstract：:A dimeric copper complex of the unsubstituted pyridoxal thiosemicarbazone (H(2)L), [[Cu(HL)(OH(2))](2)]Cl(2).2H(2)O, previously tested on Friend murine cell lines has been recently resynthesized to evaluate its behavior on different murine and human leukemic cell lines and has been compared, in vitro and in vivo, with...

journal_title：Journal of inorganic biochemistry

authors： Belicchi Ferrari M,Bisceglie F,Pelosi G,Tarasconi P,Albertini R,Dall'Aglio PP,Pinelli S,Bergamo A,Sava G

更新日期：2004-02-01 00:00:00

abstract：:A Schiff base complex of chromium(III), transdiaqua[N,N'ethylenebis (salicylideneimine)chromium(III)]perchlorate, [Cr(salen)(OH(2))(2)](+), was found to have an inhibitory effect on the growth of Shigella dysenteriae. The chromium(III) complex was found to cure (remove) the invasive plasmid and thereby render the micr...

journal_title：Journal of inorganic biochemistry

authors： Shrivastava HY,Devaraj SN,Nair BU

更新日期：2004-02-01 00:00:00

abstract：:A study has been performed of the kinetics and equilibria involved in complex formation between the macrocyclic polyamine 2,5,8,11-tetraaza[12]-[12](2,9)[1,10]-phenanthrolinophane (Neotrien) and Cu(II) in acidic aqueous solution and ionic strength 0.5 M (NaCl), by means of the stopped-flow method and UV spectrophotome...

journal_title：Journal of inorganic biochemistry

authors： Biver T,Secco F,Tinè MR,Venturini M

更新日期：2004-01-01 00:00:00

abstract：:Copper(II) and zinc(II) complexes of the peptides Ac-HisValHis-NH2 and Ac-HisValGlyAsp-NH2 related to the active site of the enzyme CuZnSOD were studied by potentiometric and spectroscopic (UV-Vis, CD and EPR) techniques. The results reveal that both ligands have effective metal binding sites, but the tripeptide is a ...

journal_title：Journal of inorganic biochemistry

authors： Bóka B,Myari A,Sóvágó I,Hadjiliadis N

更新日期：2004-01-01 00:00:00

abstract：:The pH- and time-dependent reaction of the anticancer drug carboplatin, [Pt(cbdca-kappa(2)O,O')(NH(3))(2)] (cbdca=cyclobutane-1,1-dicarboxylate), with the tripeptides H-glyglymet-OH (glycylglycyl-L-methionine) and Ac-glyglymet-OH at 313 K was investigated by high-performance liquid chromatography, NMR and mass spectro...

journal_title：Journal of inorganic biochemistry

authors： Kleine M,Wolters D,Sheldrick WS

更新日期：2003-12-01 00:00:00

abstract：:The pre-steady-state reduction of cytochrome P450 (P450) 2B4 by P450 reductase (reductase) was modeled by assuming that an equilibrium between three catalytic conformers of P450 regulates the multi-phasic reduction of the enzyme. This model was compared to a model of reduction involving a minimum number of phases. Bas...

journal_title：Journal of inorganic biochemistry

authors： Reed JR,Hollenberg PF

更新日期：2003-11-01 00:00:00

abstract：:The new potential antitumour soluble drug K[Ru(eddp)Cl(2)].3H(2)O, (eddp=ethylenediamine-N,N'-di-3-propionate) has been isolated and characterized. The analysis of the interaction of this complex with pBR322 plasmid DNA by circular dichroism spectroscopy shows that the ruthenium complex initially induces alteration of...

journal_title：Journal of inorganic biochemistry

authors： Grguric-Sipka SR,Vilaplana RA,Pérez JM,Fuertes MA,Alonso C,Alvarez Y,Sabo TJ,González-Vílchez F

更新日期：2003-10-01 00:00:00

abstract：:Three-week-old Picea abies seedlings were grown for 7 days in 100 microM aluminium (Al), combined with 1000 or 2000 microM silicon (Si). Solution pH was adjusted to 4.00, 4.25, 4.50, 4.75, or 5.00. In the absence of Si, solution pH had no effect on the decrease in root growth caused by 100 microM Al. Silicon did not a...

journal_title：Journal of inorganic biochemistry

authors： Ryder M,Gérard F,Evans DE,Hodson MJ

更新日期：2003-09-15 00:00:00

abstract：:The effect of AlCl(3) on the (Na(+)/K(+))ATPase activity of freeze-thawed synaptosomes, isolated from rat brain cortex, has been studied. The AlCl(3) action on the enzyme hydrolytic activity was examined using in vitro and in vivo approaches. Following exposure to AlCl(3) using both in vitro (synaptosomes incubated in...

journal_title：Journal of inorganic biochemistry

authors： Silva VS,Gonçalves PP

更新日期：2003-09-15 00:00:00

abstract：:A series of new platinum(II) and platinum(IV) adducts of type [P(II)(cis-1,4-DACH)LCl]NO(3,) where cis-1,4-DACH=cis-1,4-diaminocyclohexane, and L=9-ethylguanine, 1-methylcytosine, adenine, adenosine, cytosine, cytidine, guanine, and [Pt(IV)(cis-1,4-DACH)Ltrans-(X)(2)Cl]NO(3), (where Y=hydroxo or acetato), were synthes...

journal_title：Journal of inorganic biochemistry

authors： Ali MS,Khokhar AR

更新日期：2003-09-01 00:00:00

abstract：:The interactions between the nucleotides: adenosine-5'-diphosphate (ADP) and adenosine-5'-triphosphate (ATP) with spermine (Spm) and 1,11-diamine-4,8-diazaundecane (3,3,3-tet), as well as Cu(II) ions are studied. In the metal-free systems nucleotide-polyamine molecular complexes have been found to form, in which the i...

journal_title：Journal of inorganic biochemistry

authors： Gasowska A

更新日期：2003-08-01 00:00:00

abstract：:The prostate gland of humans and other animals accumulates a level of zinc that is 3-10 times greater than that found in other tissues. Associated with this ability to accumulate zinc is a rapid zinc uptake process in human prostate cells, which we previously identified as the hZIP1 zinc transporter. We now provide ad...

journal_title：Journal of inorganic biochemistry

authors： Franklin RB,Ma J,Zou J,Guan Z,Kukoyi BI,Feng P,Costello LC

更新日期：2003-08-01 00:00:00

abstract：:This work describes the synthesis and characterization of six new dinuclear platinum complexes having N,N'-di-(2-aminoethyl)-1,3-diamino-2-propanol, aryl substituted N-benzyl-1,4-butanediamines and N-benzyl-1,6-hexanediamines as ligands. They were prepared by the reaction of cis-[PtCl(2)(DMSO)(2)] (DMSO=dimethyl sulfo...

journal_title：Journal of inorganic biochemistry

authors： Cesar ET,de Almeida MV,Fontes AP,Pereira Maia EC,Garnier-Suillerot A,Rúbia Costa Couri M,de Castro Antunes Felício E

更新日期：2003-07-01 00:00:00

abstract：:The acsABCDE genes in the Clostridium thermoaceticum genome are used for autotrophic acetyl-CoA synthesis using the Wood-Ljungdahl pathway. A 2.8-kb region between acsC and acsD was cloned and sequenced. Two open reading frames, orf7 (approximately 1.9 kb) and acsF (approximately 0.7 kb) were identified. orf7 appears ...

journal_title：Journal of inorganic biochemistry

authors： Loke HK,Lindahl PA

更新日期：2003-01-01 00:00:00

abstract：:The reaction mechanism of the oxidation of 2,6-dichlorophenol (2,6-DCP) by horseradish peroxidase (HRP) and H2O2 has been investigated and the reaction products have been characterized by UV-visible and mass spectrometry. Evidence for the dimerization of 2,6-DCP to 3,3',5,5'-tetrachloro-4,4'-dihydroxybiphenyl and the ...

journal_title：Journal of inorganic biochemistry

authors： Laurenti E,Ghibaudi E,Todaro G,Pia Ferrari R

更新日期：2002-09-30 00:00:00

abstract：:The CYP121 gene from the pathogenic bacterium Mycobacterium tuberculosis has been cloned and expressed in Escherichia coli, and the protein purified to homogeneity by ion exchange and hydrophobic interaction chromatography. The CYP121 gene encodes a cytochrome P450 enzyme (CYP121) that displays typical electronic abso...

journal_title：Journal of inorganic biochemistry

authors： McLean KJ,Cheesman MR,Rivers SL,Richmond A,Leys D,Chapman SK,Reid GA,Price NC,Kelly SM,Clarkson J,Smith WE,Munro AW

更新日期：2002-09-20 00:00:00

abstract：:The redox active iron-sulfur center of bovine adrenodoxin is coordinated by four cysteine residues in positions 46, 52, 55 and 92 and is covered by a loop containing the residues Glu-47, Gly-48, Thr-49, Leu-50 and Ala-51. In plant-type [2Fe-2S] ferredoxins, the corresponding loop consists of only four amino acids. The...

journal_title：Journal of inorganic biochemistry

authors： Zöllner A,Hannemann F,Lisurek M,Bernhardt R

更新日期：2002-09-20 00:00:00

abstract：:Composites of beta-chitin with calcium carbonate polymorphs were prepared by precipitation of the mineral into a chitin scaffold by means of a double diffusion system. The beta-chitin was obtained from the pen of the Loligo sp. squid. The three main polymorphs of calcium carbonate: aragonite, calcite and vaterite, wer...

journal_title：Journal of inorganic biochemistry

authors： Falini G,Fermani S,Ripamonti A

更新日期：2002-08-30 00:00:00

abstract：:[Ru(bzimpy)(2)]Cl(2), where bzimpy is 2,6-bis(benzimidazol-2-yl) pyridine was synthesized and characterized by ESI-MS, UV-Visible, (1)H NMR and fluorescence spectra. Absorption titration and thermal denaturation experiments indicate that the complex binds to DNA with moderate strength. Viscosity measurement shows that...

journal_title：Journal of inorganic biochemistry

authors： Vaidyanathan VG,Nair BU

更新日期：2002-08-15 00:00:00

abstract：:Recent stopped-flow kinetics demonstrated the existence of an intermediate before the occurrence of the final product of the reaction of both iron-containing microperoxidase-8 (Fe(III)MP-8) and manganese-containing microperoxidase-8 (Mn(III)MP-8) with H(2)O(2). The intermediate was assigned to be (hydro)peroxo-iron. W...

journal_title：Journal of inorganic biochemistry

authors： Veeger C

更新日期：2002-07-25 00:00:00

abstract：:The Cu-containing nitrite reductase from Hyphomicrobium denitrificans (HydNIR) has been spectroscopically and functionally characterized. The visible absorption spectrum implies that the enzyme has two type 1 Cu ions in one subunit (ca. 50 kDa). The electron paramagnetic resonance (EPR) spectrum of HydNIR is simulated...

journal_title：Journal of inorganic biochemistry

authors： Deligeer,Fukunaga R,Kataoka K,Yamaguchi K,Kobayashi K,Tagawa S,Suzuki S

更新日期：2002-07-25 00:00:00

abstract：:The water-insoluble and water-soluble organotin(IV)porphinate complexes based on the tris-(4-pyridinyl)porphyrin and tris(N-methyl-4-pyridiniumyl)porphyrin moieties were synthesized and characterized by elemental analysis, (1)H NMR, IR and electrospray ionization mass spectra. The in vitro activity of the compounds ag...

journal_title：Journal of inorganic biochemistry

authors： Han G,Yang P

更新日期：2002-07-25 00:00:00

abstract：:Two DTPA derivatives, a mono-amide derivative containing an iodinated synthon, DTPA-IOPsp (L(1)) and the ligand DTPA(BOM)(3) (BOM=benzyloxymethyl) (L(2)), radiolabelled with (153)Sm(3+) and (111)In(3+), were studied as potential hepatospecific gamma scintigraphic agents. In vivo studies with Wistar rats show that the ...

journal_title：Journal of inorganic biochemistry

authors： Prata MI,Santos AC,Neves M,Geraldes CF,de Lima JJ

更新日期：2002-07-25 00:00:00

abstract：:Cadmium is a potent carcinogen in rodents and has recently been accepted by the International Agency for Research on Cancer as a category 1 (human) carcinogen, but the molecular mechanism of its action remains largely unclear. It has however been suggested that cadmium-induced carcinogenesis may involve either direct ...

journal_title：Journal of inorganic biochemistry

authors： Hossain Z,Huq F

更新日期：2002-06-07 00:00:00

abstract：:The aerobic redox reaction of Fe(III)bleomycin (Blm) and ascorbate was examined in the absence of DNA and in the presence of 7.5 and 25 calf thymus DNA base pairs per-drug molecule, in order to investigate the effect of DNA binding on the properties of FeBlm activation and DNA strand cleavage. Under these successive c...

journal_title：Journal of inorganic biochemistry

authors： Li W,Antholine WE,Petering DH

更新日期：2002-05-21 00:00:00

abstract：:Three new copper(II) complexes of stoichiometry [Cu(L-dipeptide)].nH(2)O, containing as ligands the dipeptides L-alanine-L-isoleucine, L-alanine-L-threonine and L-alanine-L-tyrosine were prepared. They were characterized by single crystal X-ray diffractometry, and electronic and infrared spectroscopy. In all cases, th...

journal_title：Journal of inorganic biochemistry

authors： Facchin G,Torre MH,Kremer E,Piro OE,Castellano EE,Baran EJ

更新日期：2002-04-28 00:00:00

abstract：:A kinetic study of CO(2) hydration was carried out using the water-soluble zinc model complex with water-soluble nitrilotris(2-benzimidazolylmethyl-6-sulfonate) L1S, [L1SZn(OH(2))](-), mimicking the active site of carbonic anhydrase, in the presence and absence of anion inhibitors NCS(-) and Cl(-). The obtained rate c...

journal_title：Journal of inorganic biochemistry

authors： Nakata K,Shimomura N,Shiina N,Izumi M,Ichikawa K,Shiro M

更新日期：2002-04-28 00:00:00